Method and microorganism for methionine production by fermentation with improved methionine excretion

摘要

The present invention relates to a recombinant microorganism optimized for fermentative production of methionine and / or a derivative thereof, and in the recombinant strain, methionine excretion is enhanced by overexpression of homologous genes of ygaZ and ygaH genes derived from Escherichia coli. Is done. The present invention includes a. A step of culturing a recombinant microorganism in an appropriate medium containing a fermentable carbon source and a sulfur source, wherein methionine excretion is excessive in ygaZ and ygaH homologous genes of ygaZ and ygaH genes derived from Escherichia coli. It also relates to a method for optimizing the fermentative production of methionine or a derivative thereof, comprising a step enhanced by expression and b. Recovering methionine and / or a derivative thereof from the medium.