1- (5-tert-Butyl-2-aryl-pyrazol-3-yl) -3- 2-fluoro-4- 3-oxo-4H-pyrido 2 as a RAF inhibitor for the treatment of cancer , 3-b pyrazin-8-yl) oxy phenyl urea derivatives

摘要

The present invention relates generally to the field of therapeutic compounds. More specifically, the present invention provides, inter alia, certain 1- (5-tert-butyl-2-aryl-pyrazol-3-yl) -3- [2 which inhibit RAF (eg, BRAF, CRAF, etc.). -Fluoro-4- [3-oxo-4H-pyrido [2,3-b] pyrazin-8-yl) oxy] phenyl] urea compounds (referred to herein as “TBAP compounds”). The invention also inhibits pharmaceutical compositions comprising such compounds, as well as RAF (eg, BRAF, CRAF, etc.); and the following disorders: proliferative disorders; cancer (eg, malignant melanoma, colon cancer, Pancreatic adenocarcinoma, etc.); inflammation; immune disorders; viral infections; fibrotic diseases; disorders associated with mutant forms of RAF (eg, BRAF, CRAF, etc.); Disorders ameliorated by inhibition of mutant BRAF; disorders ameliorated by inhibition of BRAF and CRAF; disorders associated with RAS mutation and / or MAPK pathway activation; SRC, p38, FGFRA, VEGFR- 2 (KDR) and / or in vitro and in vivo for treating disorders ameliorated by inhibition of LCK Also it relates to the use of both these compounds and compositions in. [Chemical 1]