A therapeutic agent for diseases based on the inhibitory action of macrophage migration inhibitory factor

摘要

General formula [1] "wherein R1 represents an optionally substituted C1-6 alkyl group; one of R2 and R3 represents a hydrogen atom; the other of R2 and R3 represents a hydrogen atom, substituted A benzopyran derivative represented by the above or a salt thereof is bonded to MIF, and may be an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group. It exhibits MIF inhibitory action and is useful for treatments such as treatment or prevention of diseases that show efficacy by inhibiting MIF.