Method for enhancing function of immune cells and method for evaluating multifunctionality of immune cells

摘要

Various immune cells are activated ex vivo to provide a method for enhancing the function of immune cells, and to provide immune cells with enhanced functions. Furthermore, a method for evaluating the multifunctionality of cells related to immunity is provided. According to any biguanide antidiabetic drug selected from metformin, phenformin and buformin, the multifunctionality of immune cells is increased by increasing CD8 + T cells having high IL-2, TNFα and IFNγ production ability. Can be strengthened. The multi-functionality of cells related to immunity is the number of immune cells treated with any of the biguanide antidiabetics selected from metformin, phenformin and buformin, and the control immune cells not treated with biguanide antidiabetics. It can be evaluated by comparing functionality. Increased sensitivity of immune cells to drugs when immune cells treated with any biguanide antidiabetic drug selected from metformin, phenformin and buformin are significantly more multifunctional than controls Can be evaluated.