A bare monolayer with nanopores that enables highly sensitive molecular detection and analysis

摘要

There is provided a nanopore sensor including a solid state membrane having a thickness between a first membrane surface and a second membrane surface opposite the first membrane surface that is less than about 1 nm. A nanopore extends through the membrane thickness between the first and second membrane surfaces and has a diameter that is greater than the membrane thickness. There is a connection from the first membrane surface to a first reservoir to provide, at the first membrane surface, a species in an ionic solution to the nanopore, and a connection from the second membrane surface to a second reservoir to collect the species and ionic solution after translocation of the species and ionic solution through the nanopore from the first membrane surface to the second membrane surface. An electrical circuit is connected to monitor translocation of the species in the ionic solution through the nanopore in the membrane.