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Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
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机译:化学定义的无白蛋白条件用于人多能干细胞的心肌分化
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摘要
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, by, for example, inhibiting Gsk-3 to obtain a first population of cells. Wnt/β-catenin signaling is then inhibited in the first cell population to induce cardiogenesis. One or more of these steps is performed under defined, albumin-free culture conditions.
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