首页> 外国专利> A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.

A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.

机译：用于预防，治疗和改善排尿障碍的组合物，其包含长木胡椒提取物。

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摘要

The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

机译：本发明涉及用于预防或治疗排尿功能障碍的药物组合物和用于预防或改善排尿功能障碍的保健功能食品，其包含 Piper Longum L的提取物。作为有效成分。 Piper Longum L的提取物。根据本发明的本发明不仅无害，而且通过同时参与与排尿功能障碍有关的各种机制，从而具有预防，治疗和改善排尿功能障碍的突出效果，从而可以增加排尿间隔，降低排尿压力，增加排尿困难。膀胱容量，抑制逼尿肌收缩并诱导逼尿肌松弛。 展开▼

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公开/公告号US2017095520A1

专利类型

公开/公告日2017-04-06

原文格式PDF

申请/专利权人 DONG WHA PHARM. CO. LTD.;
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申请/专利号US201515127854

发明设计人 DA-AE PARK;YOON-YOUNG CHANG;KWANG-HYUN KIM;SANG-HO LEE;CHAN-SEOK JEON;HYUN-YONG LEE;
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申请日2015-03-20

分类号A61K36/67;A23L2/52;A61K9/48;A23L33/105;A61K9;A61K9/20;

国家 US

入库时间 2022-08-21 13:46:20

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1. 包含具有丝蛋白的熟制蚕加工物及当归提取物的用于改善记忆力的组合物或用于预防及治疗阿尔茨海默氏痴呆的组合物 [P] . 中国专利： CN113226343A . 2021-08-06

2. 用于预防、改善或治疗肌肉疾病或用于改善肌肉功能的包含海菊提取物的组合物 [P] . 中国专利： CN112512543A . 2021-03-16

3. COMPOSITIONS COMPRISING AN EXTRACT OF PIPER LONGUM L. FOR PREVENTING, TREATING AND IMPROVING VOIDING DYSFUNCTION [P] . 日本专利： JP2019014761A . 2019-01-31

机译：包含用于预防，治疗和改善排尿功能障碍的PI木提取物的组合物

4. Composition for preventing, treating and improving of voiding dysfunction comprising extract from Piper longum L. [P] . 美国专利： US2018055902A1 . 2018-03-01

机译：用于预防，治疗和改善排尿功能障碍的组合物，其包含来自长胡椒的提取物。

5. A composition for preventing treating and improving of voiding disorder comprising extract from piper longum L. [P] . 韩国专利： KR101712790B1 . 2017-03-23

机译：一种用于预防和改善排尿障碍的组合物，其包含来自长胡椒的提取物。

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Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - 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An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; 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