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Synthesis of FR901464 and analogs with antitumor activity

机译：FR901464及其具有抗肿瘤活性的类似物的合成

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摘要

The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.

机译：本发明提供了FR901464的新颖类似物，以及制备FR901464及其类似物的改进方法。这些化合物显示出抗癌活性，是针对与功能异常的RNA剪接相关的多种疾病的疗法的候选物。

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公开/公告号US9771377B2

专利类型
公开/公告日2017-09-26

原文格式PDF
申请/专利权人 UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;
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申请/专利号US201314654305
发明设计人 KAZUNORI KOIDE;SAMI SAIF ELDIN ALI OSMAN;
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申请日2013-12-19
分类号C07D493/10;C07D413/14;C07D413/12;C07C49/603;C07D309/30;C07D407/06;C07D493/04;
国家 US
入库时间 2022-08-21 13:46:18

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