THERAPEUTIC OR PROPHYLACTIC AGENT FOR MULTIPLE SCLEROSIS

摘要

A therapeutic or prophylactic agent for multiple sclerosis includes as an effective component a cyclohexane derivative represented by Formula (I):; ;wherein A is a substituent represented by Formula (IIa) or (IIb):; ;R¹ and R² are each independently a hydrogen atom, chlorine atom, C₁-C₃ haloalkyl, C₁-C₄ alkyl, C₁-C₄ alkoxy, or cyano; R³ is a hydrogen atom or chlorine atom; R⁴ is a fluorine atom, hydroxymethyl, or hydroxyl; R⁵ and R⁶ are each independently a hydrogen atom, fluorine atom, C₁-C₃ haloalkyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, C₁-C₄ alkoxy, hydroxyl, or C₂-C₅ alkylcarbonyloxy, or optionally together form oxo; R⁷ and R⁸ are each independently a hydrogen atom or fluorine atom; Y is an oxygen atom or sulfur atom; and Z is a nitrogen atom or methane or a pharmaceutically acceptable salt thereof.