首页> 外国专利> Antifungal 5,6-dihydro-4H-pyrrolo1,2-a1,4benzo-diazepines and 6H-pyrrolo1,2-a1,4benzodiazepines substituted with heterocyclic derivatives

Antifungal 5,6-dihydro-4H-pyrrolo1,2-a1,4benzo-diazepines and 6H-pyrrolo1,2-a1,4benzodiazepines substituted with heterocyclic derivatives

机译：抗真菌5,6-二氢-4 H -吡咯并[1,2- a ] [1,4]苯并二氮杂和6 H 杂环衍生物取代的-pyrrolo [1,2- a ] [1,4]苯并二氮杂

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The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I); wherein R¹, R², R³, R⁴and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. 展开▼

机译：本发明涉及新颖的抗真菌5，6-二氢-4H-吡咯并-[1,2-a] [1,4]苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂式（I）的杂环衍生物; 其中R ^{1 ，R ^{2 ，R ^{3 ，R ^{4 和Het具有权利要求中定义的含义。根据本发明的化合物主要对皮肤真菌和全身性真菌感染具有活性。本发明进一步涉及制备此类新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。}}}} 展开▼

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公开/公告号US9493468B2

专利类型

公开/公告日2016-11-15

原文格式PDF

申请/专利权人 LIEVEN MEERPOEL;LOUIS JULES ROGER MARIE MAES;KELLY DE WIT;KOEN JAN LUDOVICUS AUGUSTYNS;
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申请/专利号US201214113356

发明设计人 LIEVEN MEERPOEL;LOUIS JULES ROGER MARIE MAES;KELLY DE WIT;KOEN JAN LUDOVICUS AUGUSTYNS;
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申请日2012-05-03

分类号A61K31/551;C07D487/04;A61K9/28;A61K9/48;

国家 US

入库时间 2022-08-21 13:43:03

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2. 二环苯衍生物取代的5,6-二氢-4H-吡咯并1,2-A1,4苯并二氮杂*和6H-吡咯并1,2-A1,4苯并二氮杂*新抗真菌剂 [P] . 中国专利： CN103282367A . 2013-09-04

3. NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO1,2-a1,4BENZO- DIAZEPINES AND 6H-PYRROLO1,2-a1,4BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES [P] . 世界知识产权组织专利： WO2012150305A1 . 2012-11-08

机译：新型抗真菌药5,6-二氢-4 H -吡咯并[1,2- a ] [1,4]苯并二氮杂和6 H -吡咯并[1,2- a ] [1,4]苯二氮杂二酮取代杂环衍生物

4. Antifungal 5,6-dihydro-4-(difluoroethyl)phenyl-4H-pyrrolo1,2-α1,4benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo1,2-α1,4benzodiazepine derivatives [P] . 美国专利： US9637490B2 . 2017-05-02

机译：抗真菌5,6-二氢-4-[（二氟乙基）苯基] -4 H -吡咯并[1,2-α] [1,4]苯并二氮杂和4-（二氟乙基）苯基-6 < I> H -吡咯并[1,2-α] [1,4]苯并二氮杂derivatives衍生物

5. NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO1,2-a1,4- BENZODIAZEPINES AND 6H-PYRROLO1,2-a1,4BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES [P] . 世界知识产权组织专利： WO2012084804A1 . 2012-06-28

机译：新型抗真菌药5,6-二氢-4H-吡咯并[1,2- a ] [1,4]-苯并二氮杂AND和6 H -吡咯并[1,2- < I> a ] [1,4]被二环苯衍生物取代的苯并二氮杂

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