Benzamide Compound, Pharmaceutical composition comprising it and its use for the treatment of Multiple Sclerosis and Ankylosing Spondylitis

摘要

Modulators of retinoid related Orphan Receptor G (rorg) and their use in the treatment of diseases mediated by the rorg.These compounds have the formula of benzamide (1) or one of its pharmaceutically acceptable salts, which is ru00b9 monocyclic heteroaryl: 5 to 6 members optionally substituted alkyl, optionally substituted with (i) cu2081u208bu2085 cfu2083 or (ii) or (iii) chu2082f; one to two sust Ituyentes independently selected from the group consisting of halogen, MethylMethoxy and CN; where the monocyclic heteroaryl of 5 to 6 members selected from the group consisting pirrolilo, pirazolilo, imidazolilo, oxazolilo, isoxazolilo, oxadiazolilo, thiazolyl, isotiazoiilo, tiadiazolilo, furanilo, furazanilo, tienilo, triazolilo, pyridinyl, pirimidinilo, pirida Zinilo, pirazinilo, triaziriilo, tetrazinilo, and tetrazolilo,Or n-oxides thereof; or phenyl substituted with one to two substituents selected from the group consisting of independently: CN, halogen and methyl alkyl; Ru00b2 is ru00b3 is cu2081u208bu2083; Halogen; ru2074 is H, alkyl ru2075 is cu2081u208bu2083; ru2076 is H or Methyl; and ru2077 is tetrahidrofuranilo or TETRA Hidropiranilo, wherein Said tetrahidrofuranilo or tetrahidropiranilo is optionally substituted with Methyl.Pharmaceutical composition comprising a compound of formula (1) or a pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable vehicle or component. The Compound is used in the treatment of Multiple Sclerosis and Ankylosing Spondylitis. Use of the compound. Or one of its pharmaceutically acceptable salts, for the manufacture of a Medicament.