Analysis summary of calcium phosphate and its components and uses

摘要

Permeable membrane phosphate analogues, pharmaceutical ingredients containing permeable membrane phosphate analogues, and methods for treating diseases such as ischemic ischemia and heart failure; Neurodegenerative disorders and genetic disorders affect the pentachloroenzyme system, including the extensive management of calcium phosphate analogues and their pharmaceutical components. Treatment of genetic diseases affecting the quininase system, for example,A disorder of a cretin transmitter or a disorder of cretin synthesis, including the management of phosphine analogues and their pharmaceutical components. 1. Claim 1: a formula compound (1),Formula (1a),Formula (2)Formula (3) or one of its salts; pharmaceutically acceptable solution, ceramic photometer or stereoisomer: wherein, formula (1) compounds are as follows: res-ch8323o-cd8323a;R1 is hydrogen or 2-C (O) OR-C (O) R-C (O) OCH (CH) OC (O) (CH) CH (R) NH-C (O) OCH (CH₃) OC (O) (CH₂) ₘCH (R¹¹) N (H) C (O) (CH₂) ₘCH (R¹¹) NH₂,-CH (CH₃) O-C (O) (CH₂) ₘCH (R¹¹) N (H) C (O) (CH₂) ₘCH (R¹²) N (H) C (O) (CH₂) ₘCH (R¹³) NH₂,-COC (CH) CH R-Coch8322; - ch8322; - r8313 or compounds selected from the formula group (4);N is an integer from 1 to 2; m is an integer from 0 to 1; each R 1,R¹² and R¹³ is, independently, an amino acid side chain; R¹⁹ is hydrogen, -C₁₋₈-alkyl or -C₁₋₆-alkyl,a. Replaced by a major hydroxyl, anthrax, or ammonia group; each R2 is an independent hydrogen, hydrocarbon c833318321; andC₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl C₄₋₂₀-substituted cycloalkylalkyl, C₄₋₂₀-heterocycloalkylalkyl,e. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; each R³ and R⁴ is independently hydrogen, C₁₋₁₂-alkyl or C₁₋₁₂-substituted alkyl; R²³ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₅₋₁₂-cycloalkyl,C₅₋₁₂-substituted cycloalkyl, C₅₋₁₂-aryl and C₅₋₁₂-substituted aryl, -C (O) -OR²² or -C (O) -R²²;R²² is C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; R⁴⁸ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₅₋₁₂-aryl,arilo C sustituido cicloalquilo C o cicloalquilo C sustituido Y es -NHCH (R) C (O) OR-83099,Or by a set of formulas (5);X is O or S; each R⁵ and R⁶ is independently hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; R⁹ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl,e. Heterosexuality;Instead, - C (o) r83099,-C (O) ORC (O) (NR R)-C (R R) -C (O) OR-C (R R) - (O) C (O) -RC (R R) - (O) C (O) -OROr by a set of formulas (6);R²⁵ is C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; and R²⁰ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₅₋₁₂-aryl,C₅₋₁₂ substituted aryl, C₃₋₁₂ cycloalkyl,a. A compound (7) substituted by or selected from the formula group;a. The compounds of formula (1a) are listed as follows: and es-nhc (R1) C (o) ORRO 83044;-83099,Or by a set of formulas (5);X is O or S; each R⁵ and R⁶ is independently hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; R⁹ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl,a. Unorthodox c832626;C (O) ORC (O) (NR R)-C (R R) -C (O) OR-C (R R) - (O) C (O) RC (R R) - (O) C (O) -OROr by a set of formulas (6);R²⁵ is C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; R²⁰ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₅₋₁₂-aryl,C₅₋₁₂ substituted aryl, C₃₋₁₂ cycloalkyl,C₃₋₁₂-substituted cycloalkyl, or a compound from the group of formulas (7);R, R1,R3,R830808,R83099,R8310,R1,R²² and R²³ are as defined herein; wherein the compound of formula (2) is as detailed below, where Y and Z are each, independently, NHCH (R¹¹) C (O) OR²⁰,-83099,Or compounds selected from the formula group (5);X is O or S; each R⁵ and R⁶ is independently hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; R⁹ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,arilalquilo C sustituido heteroarilalquilo C heteroarilalquilo CInstead, - C (o) r83099,C (O) ORC (O) (NR R)-C (R R) -C (O) OR-C (R R) - (O) C (O) RC (R R) - (O) C (O) -OROr by a set of formulas (6);R²⁵ is C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,C₆₋₂₀-substituted arylalkyl, C₆₋₂₀-heteroarylalkyl or C₆₋₂₀-substituted heteroarylalkyl; R²⁰ is hydrogen, C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₅₋₁₂-aryl,C₅₋₁₂ substituted aryl, C₃₋₁₂ cycloalkyl,C₃₋₁₂-substituted cycloalkyl, or a compound from the group of formulas (7);R, R1,R3,R830808,R83099,R8310,R1,2. R2 and R2 3 are defined in this document; in this document, the compounds of formula (3) are as follows, wherein 1 and 1 are independent; NHC (R1) C (o) or * 83044;-83099,Or by a set of formulas (5);1. Y1 and Z1 cannot be a set of formulas (8) at the same time;R²⁵ is C₁₋₁₂ alkyl,C₁₋₁₂-substituted alkyl, C₁₋₁₂-heteroalkyl,C₁₋₁₂-substituted heteroalkyl, C₃₋₁₂-cycloalkyl,C₃₋₁₂-substituted cycloalkyl, C₄₋₂₀-cycloalkylalkyl,cicloalquilalquilo C sustituido heterocicloalquilalquilo Ce. Straight ring tequila;C₅₋₁₂ substituted aryl, C₅₋₁₂ heteroaryl,C₅₋₁₂ substituted heteroaryl, C₆₋₂₀ arylalkyl,arilalquilo C sustituido heteroarilalquilo C o heteroarilalquilo C sustituido y R RR3,R830808,R83099,R8310,R1,2.2.1.2 and 2.3 are defined in this article.