Peptides and Derivatives of peptides cholecystokinin (CCK) and their uses

摘要

According to the general formula (1): p-l-x1-x2-x3 gly-trp-x8310a-dmasp-x831222-nh832222 (1) derivative;P is the chemical formula: HOOC (ch8322) 739co - *,If x is an integer in the range of 12-18, l is absent, or l contains at least one related element selected from the chemical formula: * * - nh-ch (COOH) - (ch832222) 8322co - *,Chemical formula: * * - NH - (CH 83222) 832222 - [O - (ch832222) 8342; - O - [ch8322]; 8345; - co - * where k is an integer in the range of 1-11, n is an integer in the range of 1-5, chemical formula: * * - nh-ch (ch8322;) - co - *,Chemical formula: * * - nh-ch832222-co-**Y / O chemical formula: * - nh-ch [(ch832222) 8324-nh8322] - co - *;X1 absent, ASP, DASP, BASP, DBSAT, Glu, O dglu; x2 PE (4-sulfetilo) or STYR; X3 NLE, Leu, ala, ile, Lys, Arg, pro, met, Phe, Ser, his o Val; X 8310es NLE, ile, Gln, met, met (o832222);Leu, Val, pro, HPG, O ala; x831222 is Phe, mephe, 1nal, me1nal, 2nal, me2nal, Trp, O metrp. It also refers to CCK related peptides and methods of preparing peptides and derivatives. It also involves the use of pharmaceutical ingredients and derivatives, especially in the treatment of obesity and related health problems, in which case the compound can be used alone or in combination with other weight loss agents, and can be chosen, in addition to diet and exercise. The derivative has strong power for CCK-1 (CCK-1R) receiver,Compared with CCK-2R, CCK-1R is highly selective, has an impact on food intake in vivo, has a long half-life and is very stable chemically.