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spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction.

机译:螺氨基化合物适合于治疗尤其是睡眠障碍和药物成瘾。

摘要

The invention concerns a spiro-amino compound of Formula (VI) wherein m is 1 or 2 or 3, n is 1 or 2, R is selected from a 5- or 6-membered aromatic ring and a 5-or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O e N, such ring being substituted with one or two substituents selected from the group consisting of (C 1 -C 3 )alkyl, (C 3 -C 5 )cycloalkyloxy, (C 1 -C 3 )alkylcarbonyl, phenyl optionally substituted with one or more halogen atoms, a 5- or 6-membered heterocycle comprising at least one nitrogen atom; P is a substituent Q or COQ, wherein Q is selected from the group consisting of phenyl, pyridil, pyrimidil, quinolyl, isoquinolyl, quinoxalyl, benzofuranyl, imidazotriazolyl, being such Q optionally substituted with one or more substituents selected from the group consisting of (C 1 -C 3 )alkyl, halogen, trifluoromethyl, carbammido, methylcarbammido, carboxy.
机译:本发明涉及式(VI)的螺氨基化合物,其中m为1或2或3,n为1或2,R 2选自5或6元芳族环和5或6元杂芳族包含1-3个选自S,O e N的杂原子的环,该环被一个或两个选自(C 1 -C 3)烷基,(C 3 -C 5)环烷氧基,(C 1)的取代基取代-C 3)烷基羰基,任选地被一个或多个卤素原子取代的苯基,包含至少一个氮原子的5元或6元杂环; P是取代基Q或COQ,其中Q选自苯基,吡啶基,嘧啶基,喹啉基,异喹啉基,喹喔啉基,苯并呋喃基,咪唑三唑基,该Q任选地被一个或多个选自以下的取代基取代: C 1 -C 3)烷基,卤素,三氟甲基,氨基甲酰氨基,甲基氨基甲酰氨基,羧基。

著录项

  • 公开/公告号BR112012001031A2

    专利类型

  • 公开/公告日2016-11-22

    原文格式PDF

  • 申请/专利权人 ROTTAPHARM S.P.A.;

    申请/专利号BR20121101031

  • 发明设计人 ROVATI LUCIO;STASI LUIGI PIERO;

    申请日2010-07-15

  • 分类号C07D401/12;A61K31/438;A61P25/30;C07D401/14;C07D417/06;C07D417/14;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:53

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