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Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction

机译:适用于治疗尤其是睡眠障碍和药物成瘾的螺氨基化合物

摘要

The present invention has the following formula (VI); m is 1 or 2 or 3, n is 1 or 2, R is a 5-membered or 6-membered aromatic ring, and a 5-membered ring containing 1 to 3 heteroatoms selected from S, or 6-membered heteroaromatic ring is selected from the ring is (C 1 -C 3) alkyl, a halogen atom, (C 3 -C 5) cycloalkyl-oxy, (C 1 -C 3) alkyl-carbonyl, optionally Phenyl substituted by one or more halogen atoms, a 5-membered or 6-membered heterocycle containing one or more nitrogen atoms; P is a substituent Q or COQ wherein Q is selected from the group consisting of phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, quinoxalyl, benzofuranyl, imidazotriazolyl, 1 -C 3) alkyl, Fig halogen, trifluoromethyl, carboxylic already in night, methylcarbamoyl night imido, carboxy, optionally substituted by one or more substituents selected from the group consisting of carboxy-methyl; Lt; RTI ID = 0.0 pharmaceutically / RTI acceptable salt thereof:
机译:本发明具有下式(VI); m为1或2或3,n为1或2,R为5元或6元芳族环,并且选择含有1至3个选自S的杂原子或6元杂芳族环的5元环。环上是(C 1 -C 3)烷基,一个卤原子,(C 3 -C 5)环烷基-氧基,(C 1 -C 3)烷基-羰基,任选被一个或多个卤素原子,5元或6元杂环取代的苯基含有一个或多个氮原子; P是取代基Q或COQ,其中Q选自苯基,吡啶基,嘧啶基,喹啉基,异喹啉基,喹喔啉基,苯并呋喃基,咪唑三唑基, 1 -C 3)烷基,图1是卤素,三氟甲基,已在夜间的羧酸,甲基氨基甲酰基夜间的亚氨基,羧基,任选被一个或多个选自羧甲基的取代基取代; Lt;其药学上可接受的盐:

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