tissue regeneration promoter using recruitment of bone marrow mesenchymal stem cells and / or pluripotent stem cells in blood

摘要

tissue regeneration promoter using recruitment of bone marrow mesenchymal stem cells and / or pluripotent stem cells in blood. Intravenous administration of hmgb-1 and s100a8 has been shown to promote skin ulcer healing by recruiting bone marrow derived cells to the skin ulcer site. In addition, that hmgb-1 was intravenously administered to cerebral infarction model mice after brain infarction was created, bone marrow-derived cells expressing nerve cell markers were detected in the brain. a remarkable cerebral infarct-reducing effect was observed in mice intravenously administered hmgb-1 compared with the control. The post-cerebral infarction survival rate was increased in the intravenous hmgb-1 administration group. The involvement of pluripotent bone marrow stem cells in the bone fracture healing process was evaluated using mice, and the result showed that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.