vaccine vehicle to induce cellular immune response, vaccine composition, and use of vaccine composition

摘要

vaccine vehicle to induce cellular immune response, vaccine composition, and use of the vaccine composition. The present invention relates to the field of biotechnology applied to human health. The invention discloses a vaccine carrier wherein the toxins of eukaryotic organisms are encapsulated in multilayered lipid liposomes obtained by the dehydration / rehydration process, the lipid composition of which is dipalmitoiphosphatidylcholine: cholesterol in a molar ratio of 1.1; which are determined for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The disclosed compositions allow modulation of the specific Î ± 1 immune response to one or more coencapsulated antigens on the toxin-containing liposomes. The vaccine vehicle of the present invention has advantages compared to others described in the prior art because of the strong and functional nature of the induced immune response and also their immunomoduction properties.