combination of panobinostat and ruxolitinib in the treatment of myeloproliferative cancer

摘要

patent combination: "combination of panobinostat and ruxolitinib in the treatment of myeloproliferative neoplasia cancer". The present invention relates to a combination comprising: (a) compound a ((r) -3- (4- (7h-pyrrol [2,3-d] pyrimidin-4-yl) -1h-pyrazol-1 -yl) -3-cyclopentylpropanenitrile) of formula (a): or one of its pharmaceutically acceptable salts; and (b) compound b (n-hydroxy-3- [4 - [[[[2- (2-methyl-1h-indol-3-yl) ethyl] amino] methyl] phenyl] -2e-2-propenamide ) of formula (b): or one of its pharmaceutically acceptable salts; for simultaneous, concomitant, separate or sequential use, especially for use in the treatment of proliferative diseases. The invention also relates to pharmaceutical compositions comprising such a combination and a method for treating proliferative diseases in a mammal, especially in humans, with such combination. The present invention also further relates to a package or commercial product comprising such a combination.