Process for encapsulating a hydrophobic active in a mesocu00e1psula of core - shell, and use of a dispersion of a core - shell mesocu00e1psula

摘要

Described are processes for encapsulating a hydrophobic active in a core-shell mesocapsule comprising preparing a high internal phase ratio emulsion having a continuous aqueous phase and a dispersed oil phase comprising at least one hydrophobic active and one or more pre-polymers, reducing the volume fraction of the high internal phase ratio emulsion below 0.74 with an aqueous phase stream, and then forming a dispersion of core-shell mesocapsules containing hydrophobic active by either: i) allowing the reduced volume fraction emulsion to sit for 12 hours when the pre-polymer is isocyanate, or ii) contacting the reduced volume fraction emulsion with a third aqueous stream comprising a cross-linking agent.