benzamide derivatives for inhibition of abl1, abl2 and bcr-abl1 activity

摘要

Patent Summary: "Benzamide derivatives for inhibition of abl1, abl2 and bcr-abl1 activity". The present invention relates to compounds of formula (I): wherein y, y, r, r2, r3 and r4 are defined in the summary of the invention; capable of inhibiting the tyrosine kinase enzymatic activity of abelson protein (abl1), abelson-related protein (abl2) and related chimeric proteins, in particular bcr-abl1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.