compound, pharmaceutical composition, glucokinase activating agent, hypoglycemic agent, agent for preventing and / or treating at least one disease, methods for activating glucokinase, for lowering blood glucose level and for preventing and / or treating at least one disease , and, use of a compound

摘要

1/1 summary “compound, pharmaceutical composition, glucokinase activating agent, hypoglycemic agent, agent to prevent and / or treat at least one disease, methods to activate glucokinase, to decrease blood glucose and to prevent and / or treat at least one disease, and use of a compound is the purpose of the invention to create a compound that selectively activates glucokinase in the ventilator and, in in particular, to provide a drug having a low hypoglycemic risk for the treatment and prevention of diabetes and impaired glucose tolerance. a compound represented by the general formula (1) [in the formula (1), ring a shows a thiazolyl group, pyridyl group, pyrazyl group, or pyrazolyl group; 1 shows - (co) -, - (cs) -, or 1 -so -; and r shows an alkyl group, hydroxy and alkyl group, c 2-6 1-6 1- alkoxy group, amino group, alkylamino group, hydroxyamino group, n-6 1-6 3 alkylcarbamoyl group, or group represented by of formula (2), r shows here 1-6 an alkyl group; r shows a hydrogen atom, 1-6 halogen atom, c-alkyl group, c-alkoxy group, or carboxyl group] or a 1-6 1-6 salt thereof or a solvate thereof.