solid dispersion with improved solubility comprising the tetrazole derivative as an active ingredient

摘要

summary "improved solubility solid dispersion comprising the tetrazole derivative as an active ingredient" is an amorphous solid dispersion comprising a tetrazole derivative of formula (i) or a pharmaceutically acceptable salt thereof as an active ingredient. The solid dispersion of the present invention comprises a water-soluble polymer or an acid so as to improve the solubility of its active ingredient, i.e. the tetrazole derivative of formula (i), thereby improving its absorption rate and thereby , can be effectively used to reduce multidrug resistance (mdr) in cancer cells.