telomerase-mediated telomer altering compounds

摘要

patent summary: "telomerase-mediated telomer altering compounds". The present disclosure relates to pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and the like for the treatment of cancer and other hyperproliferative diseases. The disclosed compounds can be converted to telomer substrates in vivo and can be recognized by telomerase for incorporation into telomeres of active telomerase cells, leading to the induction of telomerase active cell death. 1/1