farnesoid x receptor inhibitors and uses in medicine

摘要

summary "farnesoid x receptor inhibitors and uses in medicine" farnesoid x receptor inhibitors, for example of formula (i), wherein r1, r2, r4, x, y, z, men are defined in this report, which are Useful in the treatment or prevention of obesity, type 2 diabetes / insulin resistance and nonalcoholic steatosis liver disease in a mammal in need thereof are disclosed. A composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method for inhibiting a farnesoid x receptor in a mammal and a method for treating or preventing obesity in a mammal is also disclosed.