Inhibitors of the farnesoid x receptor and uses in medicine

摘要

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R¹, R², R⁴, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.;