Anti IL - 18

摘要

Il-18 participates in both innate and acquired Immunity. The bioactivity of IL - 18 is negatively regulated by the Protein Binding to IL - 18 (il18bp), an inhibitor of Natural Origin and highly specific. This Protein forms a complex with soluble IL - 18 free that prevents its interaction with the receptor and inhibiting il-18 neutralizing, therefore, its biological activity.The present Invention discloses Link Molecules, particularly Antibodies or Fragments thereof that bind to il-18 and does not bind to il-18 linked to il-18bp (complex of il-18 and il-18bp). Apart from its Physiological function, it has been demonstrated that il-18 mediates a variety of autoimmune and inflammatory diseases.Link the Molecules of the invention can be used as Therapeutic molecules for the treatment of autoimmune and inflammatory diseases associated with IL - 18, or as diagnostic tools to detect, measure and / or il-18 and il-18bp not linked to the Comp Onente of total reserves of il-18.