Modification of intrinsically disordered sequences for vaccine preparation

摘要

Preparation of a compound to cause immune reactions by introducing the compound into a living organism, where the compound is the product of one or more peptides corresponding to intrinsically disordered sequences determined by the implementation of Foldindex software, and the peptides are irreversible and covalently modified on secondary amino functions of amino acids, is claimed. An independent claim is included for the compound obtained by the process, where the compound contains one or part of the protein sequences comprising one of 58 fully defined 5-93 amino acid sequences (SEQ ID NO: 1-58) given in the specification. e.g. Val Lys Lys Ile Pro Lys Lys Pro (SEQ ID NO: 8) Phe Leu Arg Arg Lys Arg Asp (SEQ ID NO: 24) Arg Glu Lys Ser Lys Lys Tyr Ser (SEQ ID NO: 33) Glu Arg Lys Glu Lys Gly (SEQ ID NO: 36) Glu Lys Lys Lys Lys Ile Thr Val (SEQ ID NO: 49) Leu Arg Ile Lys Lys Lys Lys Glu (SEQ ID NO: 52) Phe Lys Lys Glu Lys Asn (SEQ ID NO: 56) ACTIVITY : Immunomodulator; Cytostatic; Cardiovascular-Gen; Hypotensive; Antiarteriosclerotic; Ophthalmological; Osteopathic; Cerebroprotective; Antiparkinsonian; Neuroprotective; Nootropic; Nephrotropic. MECHANISM OF ACTION : None given.