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RECONSTITUTED HIGH-DENSITY LIPOPROTEIN FORMULATION AND PROCEDURE FOR PREPARING IT
RECONSTITUTED HIGH-DENSITY LIPOPROTEIN FORMULATION AND PROCEDURE FOR PREPARING IT
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机译:重构的高密度脂蛋白配方及其制备方法
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摘要
A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAl or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50g/L and the molar ratio of apolipoprotein:lipid is optimally in the range 1:40 to 1:75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction.
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