RAPAMYCIN FORMULATION ENCAPSULATED IN RECONSTITUTED HIGH-DENSITY LIPOPROTEIN CONTAINING V156K-APOA-I

摘要

PURPOSE: A rapamycin formulation using recombinant high density protein containing apolipoprotein mutant is provided to improve solubility of rapamycin and suppress aging and arteriosclerosis. CONSTITUTION: A rapamycin formulation contains 0.1-10 weight parts of rapamycin based on total 100 weight parts of recombinant high density lipoprotein and apolipoprotein mutant V156K. The recombinant high density lipoprotein contains apolipoprotein mutant V156K, phospholipid, cholesterol, and sodium cholate. The rapamycin formulation is used for preventing aging and arteriosclerosis.