首页> 外国专利> ANHYDROUS CRYSTAL FORM OF FREE BASIS OF 6- {2- 1- (6-METHYL-3-PYRIDAZYNYL) -4-PIPERIDINYL ETOXI} -3-ETOXI-1,2-BENZOZAZOLE

ANHYDROUS CRYSTAL FORM OF FREE BASIS OF 6- {2- 1- (6-METHYL-3-PYRIDAZYNYL) -4-PIPERIDINYL ETOXI} -3-ETOXI-1,2-BENZOZAZOLE

机译:6-{2- [1- [1-(6-甲基-3-吡啶并辛基)-4-哌啶基]乙氧基}的游离基的无水晶体形式-3-乙氧基-1,2-苯并唑

摘要

A crystalline form of 6- {2- [1- (6-methyl-3-pyridazinyl) -4-piperidinyl] ethoxy} -3-ethoxy-1,2-benzoxazole is proposed, which is useful in the treatment of infections caused by Picornaviridae, such as human rhinovirus (HRV), and in particular, the crystalline form is the anhydrous crystalline form of the 6- {2- [1- (6-methyl-3-pyridazinyl) -4-piperidinyl] ethoxy} -3-ethoxy-1 free base , 2-benzoxazole. In addition, a method for producing a crystalline form of the free base is also proposed, including a step of finely grinding the compound particles, optionally using a wetting agent, and also offers pharmaceutical compositions comprising a crystalline form of the free base, such as tablets or suspensions, and methods of therapy using this form and their pharmaceutical compositions.
机译:提出了6- {2- [1- [1-(6-甲基-3-哒嗪基)-4-哌啶基]乙氧基} -3-乙氧基-1,2-苯并恶唑的晶体形式,其可用于治疗由感染引起的感染。由Picornaviridae,例如人鼻病毒(HRV),特别是结晶形式是6- {2- [1- [1-(6-甲基-3-哒嗪基)-4-哌啶基]乙氧基}的无水结晶形式。 3-乙氧基-1游离碱,2-苯并恶唑。另外,还提出了一种制备游离碱的结晶形式的方法,该方法包括以下步骤:任选地使用润湿剂将化合物颗粒精细研磨,并且还提供了包含游离碱的结晶形式的药物组合物,例如片剂或混悬剂,以及使用该形式及其药物组合物的治疗方法。

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