PEPTIDE WHICH IS A FRAGMENT OF FACTOR VIII, AND COMPOSITION FOR SUPPRESSING OR PREVENTING THE PRODUCTION OF FACTOR VIII INHIBITOR ANTIBODIES IN VIVO

摘要

The present invention relates to a peptide, which is a fragment of factor VIII, which suppress or prevent the production of factor VIII inhibitor antibodies in vivo, and which consists of the sequence EDNIMVTFRNQASR. Moreover, the invention relates to a composition for suppressing or preventing the production of factor VIII inhibitor antibodies in vivo, comprising said peptide. The present invention also relates to the use of said peptide or said composition for suppressing or preventing the production of factor VIII inhibitor antibodies in vivo. The invention allows to reduce the amount of FVIII which is necessary for the administration thereof in order to improve blood coagulation in a patient.