WAYS TO REDUCE THE IMMUNOGENICITY OF BLOOD VIRTUAL FACTOR VIII IN PATIENTS GETTING TREATMENT BY FACTOR VIII

摘要

The present invention provides methods for administering chimeric and hybrid factor VIII (FVIII) polypeptides, consisting of parts of FVIII and Fc, to subjects at risk of developing inhibitory immune reactions, including the appearance of antibodies to FVIII and / or cell-mediated immunity. The introduction of such polypeptides is sufficient to activate coagulation and induce immune tolerance to FVIII. Such a chimeric polypeptide may contain a full-length FVIII or FVIII polypeptide, including a deletion, for example, a complete or partial deletion of the B-domain.