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NOVEL LIPID DRUG CONJUGATES FOR IMPROVED ORAL DELIVERY OF AMPHOTERICIN B AND NANOFORMULATIONS THEREOF
NOVEL LIPID DRUG CONJUGATES FOR IMPROVED ORAL DELIVERY OF AMPHOTERICIN B AND NANOFORMULATIONS THEREOF
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机译:新型脂质药物缀合物可改善两性霉素B的口服释放量和纳米制剂
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摘要
The present invention relates to the development of the orally administrable lipid conjugates of hydrophilic or amphiphilic drugs. More specifically, it relates to the class of amphiphilic drugs such as Amphotericin B for improving their suitability for nanodrug delivery systems. The nanoformulations prepared using the drug lipid conjugate shows increased oral bioavailability, therapeutic efficacy and safety profile of drugs in concern. The nanoformulations provide high level of manufacturing scalability and industrial adaptability.
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