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MUTANT ENZYME AND PRODUCTION METHOD FOR TERPENOID USING SAID MUTANT ENZYME
MUTANT ENZYME AND PRODUCTION METHOD FOR TERPENOID USING SAID MUTANT ENZYME
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机译:所说突变酶的突变酶及类萜的生产方法
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摘要
The purpose of the present invention is to efficiently produce a useful terpenoid compound and in particular to provide a production method for squalene being an important intermediate of terpenoid. Said issue can be solved by a hydroxymethylglutaryl CoA reductase (HMGR) including: (a) an amino acid other than an analine (A) at position 10 in an Sa2 amino acid sequence; (b) an amino acid other than a proline (P) at position 1 from the C end of a DKK area in an HMG CoA bond site; (c) an amino acid other than an analine (A) at position 1 in an La2 amino acid sequence; and (d) an amino acid other than a glutamic acid (E) at position 6 in an La2 amino acid sequence.
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