A NOVEL PROCESS FOR THE PREPARATION OF METHYL (2S)-1-{(6S)-6-5-(9,9-DIFLUORO-7- {2-(1R,3S,4S)-2-{(2S)-2-(METHOXYCARBONYL)AMINO-3-METHYLBUTANOYL}-2-AZABICYCLO2.2.1HEPT-3-YL- 1H-BENZIMIDAZOL-6-YL}-9H-FLUOREN-2-YL)-1H-IMIDAZOL-2-YL-5-AZASPIRO2.4HEPT-5-YL}-3-METHYL-1- OXOBUTAN-2-YLCARBAMATE

摘要

ABSTRACT: The present invention relates to a novel process for the preparation of methyl[(2S)-1-{(6S)-6-(5-(9,9-difluoro-7-{2- [(lR,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbu-tanoyl} -2-azabicyclo[2.2.1 ]hept-3-yl]-1 H-benzimidazol-6-yl} -9H- ftuoren-2-yl)-1 H-imidazol -2-yl]-5-azaspiro[2.4.]hept-5-yl}-3-methyl-l-oxobutan-2-yl]carbamate of formula-I