STARCH PHTHALATE BASED FAST DISSOLVING FORMULATIONS FOR IMMEDIATE RELEASE AND ENHANCED DISSOLUTION RATE OF ACTIVE PHARMACEUTICAL INGREDIENTS

摘要

The present invention relates to the field of pharmaceutical technology and describes preparation of starch phthalate, a modified starch and novel fast dissolving systems employing starch phthalate for obtaining immediate release of active pharmaceutical ingredients (APIs) and enhanced dissolution rate. The starch phthalate, novel superdisintegrant is suitable for producing fast dissolving systems of large number of APIs with enhanced dissolution rate and dissolution efficiency within 15 minutes. In the new fast dissolving systems an active ingredient is present composed of starch phthalate with additives such as diluents. The fast dissolving systems are in the form of compressed tablets as a platform technology for immediate release of APIs belonging to different chemical and pharmacologic categories which require immediate release formulation. The fast dissolving systems employing starch phthalate are suitable for immediate release of several APIs.