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PEPTIDE VACCINES FOR CANCERS EXPRESSING MPHOSPH1 OR DEPDC1 POLYPEPTIDES
PEPTIDE VACCINES FOR CANCERS EXPRESSING MPHOSPH1 OR DEPDC1 POLYPEPTIDES
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机译:表达MPHOSPH1或DEPDC1多肽的癌症的肽疫苗
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摘要
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID No: 7,8,9,lO,Il,12,192,195, 197, 209, 225,226, 228,230, 240, 241, 243, 244, 249, 253, 254 or 255, as well as peptides having the above mentioned amino acid sequences in which 1,2, or several amino acids are substituted, deleted, or added, wherein the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with the over-expression of MPHOSPHI and/or DEPDC1, e.g. cancers, containing these peptides as an active ingredient. The peptides of the present invention can also be used as vaccines.
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机译:本发明提供了具有如SEQ ID No:7、8、9、10、11、12、192、195、197、209、225、226、228,230、240、241、243、244、249、253, 254或255,以及具有上述氨基酸序列的肽,其中1、2或几个氨基酸被取代,缺失或添加,其中所述肽具有细胞毒性T细胞诱导性。本发明还提供了用于治疗或预防与MPHOSPHI和/或DEPDC1的过表达有关的疾病的药物,例如MPHOSPHI和/或DEPDC1。含有这些肽作为有效成分的癌症。本发明的肽也可以用作疫苗。
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