SYNTHESIS OF NOW FLUCONAZOLE ANALOGUES CONTAINING 1,2,3-TRIAZOLE MOIETY AND HAVING BETTER ANTIFUNGAL SPECTRUM

摘要

The need for new class of antifungal drugs with high efficacy and low toxicity is well established. Synthesis and antifungal activity of new analogues of the azole antifungal drug fluconazole, 1 -(1 H-1,2,4-triazol-1 -yl)-2-(2,4-difluorophenyl)-3-(4-substituted-1,2,3-triazol-1 -yl)-2-propanols of formula (1) and l-(lH-l,2,4-triazol-l-yl)-2-(2,4-difluorophenyl)-3-(N-substituted-l,2,3-triazol-4-yl)-2-propanols is described. These compounds were found to be less toxic than antifungal drug ketoconazole.