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NEW POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS
NEW POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS
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机译:利福昔明的新形态,其制备方法及其在药物制剂中的使用
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摘要
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin 6 and rifaximin E useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by 10 means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the 15 invention.
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