TOPICAL FORMULATION PROCESS BASED ON METALLIC NANOPARTICLES AND THEIR OXIDES FOR THEIR APPLICATION AS AN ANTIMICROBIAL AGENT AND TISSUE REGENERATOR.

摘要

The present disclosure is related to a cream composition with antimicrobial properties; the composition consists of two steps: A) Preparing metal nanoparticles by chemical precipitation by: (I) stirring and heating an ethanol solution with a soluble precursor, (II) adding a water soluble precipitating agent to produce a precipitation reaction in order to form metallic nanoparticles, (III) separating the metal nanoparticles from the solution and (B) incorporating the metal oxides nanoparticles into the cream composition, by ultrasound, to disperse the NPs in aloe vera, or in at least one oil, glycerin and at least one emulsifier. Another object of the present invention is to provide a use of an antimicrobial cream composition to produce materials and/or nanocomposites with antimicrobial and healing properties, such as wound dressings, adhesives for medical use, etc.