Benzamide derivatives for the inhibition of the activity ABL2 ABL1, and BCR - ABL1

摘要

The present Invention relates to Derivatives of benzamide compounds of formula (i), or pharmaceutically acceptable salts of thereof, wherein: R1 is pirazolilo optionally substituted with 1 to 2 groups R6, R7 R2 is replaced with pirrolidinilo; R3 is H or Halogen; R4 is sedan - CF2 - or - y2 y3 R6; h, Among others; R7 is hydroxyl, hydroxyl, Methyl, among others; and Y1 and Y2 are CF2 is n or CH,;- or or - S (o) 0 - 2; Y3 h, Chlorine, among others. It is a Preferred compound: (R) - N - (4 - (chloro difluoro methoxy) - phenyl) - 6 - (2 - hydroxy - pyrrolidin-1-yl) - 5 - (1h pyrazole - 5 - il) - Nicotinamide, among others. It also relates to a Pharmaceutical composition.These compounds inhibit the Enzymatic activity of the Protein Tyrosine Kinase Abelson, ABL1, ABL2 and chimeric protein BCR - ABL1, being useful in the treatment of cancer