GLUCOCORTICOID RECEPTOR AGONIST COMPRISING 2, 2, 4- TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING SUBSTITUTED OXY GROUP

摘要

THE PRESENT INVENTION IS RELATED TO GLUCOCORTICOID RECEPTOR AGONISTS COMPRISED OF A COMPOUND REPRESENTED BY FORMULA (1) WHICH IS 2,2,4-TRIMETHYL-6-PHERNYL-1,2- DIHYDROQUINOLINE DERIVATIVE OR A SALT THEREOF AND NOVEL PHARMACOLOGICAL EFFECTS OF THE GLUCOCORTICOID RECEPTOR AGORNISTS. IN THE FORMULA (1), R1 REPRESENTS FORMULA (2A), (3A), (4A) OR (5A)’; R2 REPRESENTS -(CQ)-R8, -(CO)O-R9, OR THE LIKE; R2-O- IS SUBSTITUTED AT THE 4- OR -5-POSITION OF BENZENE RING A; R3 REPRESENTS A LOWER ALKYL GROUP; R4, R5, R6 OR R7 REPRESENTS A HALOGEN ATOM, A LOWER ALKYL GROUP WHICH MAY HAVE A SUBSTITUENT, OR THE LIKE; M, N, P OR Q REPRESENTS 0,1 OR THE LIKE; R8, R9 OR THE LIKE REPRESENTS A LOWER ALKYL GROUP WHICH MAY HAVE A SUBSTITUENT, A LOWER ALKENYL GROUP, OR THE LIKE.