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DNA MINOR GROOVE BINDING AGENT IMMUNOCONJUGATES, COMPOSITION CONTAINING THEM AND METHODS OF MAKING AND USE
DNA MINOR GROOVE BINDING AGENT IMMUNOCONJUGATES, COMPOSITION CONTAINING THEM AND METHODS OF MAKING AND USE
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机译:DNA微小沟槽结合剂免疫缀合物,包含它们的组合物以及制造和使用方法
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摘要
An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
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