NEW TARGETS MODULATED BY A CASUAL VARIANT OF TYPE 2 DIABETES (T2D) EMBEDDED WITHIN THE TCF7L2 GENE AND METHODS OF USE THEREOF FOR IDENTIFYING AGENTS HAVING EFFICACY FOR THE TREATMENT OF TYPE 2 DIABETES AND OTHER METABOLIC DISORDERS

摘要

Compositions and methods are provided which modulate the enhancer/silencer function embedded within TCF7L2 for treating metabolic disease including T2D are disclosed.