HISTONE DEACETYLASE INHIBITION ENHANCES ANTIMICROBIAL PEPTIDE BUT NOT INFLAMMATORY CYTOKINE EXPRESSION UPON BACTERIAL CHALLENGE

摘要

The present invention relates to methods and therapeutic uses of histone deacetylase (HDAC) inhibitors for increasing antimicrobial peptides (AMP), particularly AMP beta- defensin-2 (DEFB2), expression in a cell in which the level of the AMP (e.g., DEFB2) has already been increased by the presence of a microbial organism, preferably a bacterium. The HDAC inhibitor further increases AMP expression compared to the microbial organism alone. In this context, HDAC inhibitors may be used for treating infections, in particular infections caused by bacteria, and dysbiosis-driven diseases.