#$%^&*AU2016102153A420170216.pdf#####ABSTRACT Hydroxylamine azole cephalosporin propylene glycol drug intermediates D-a- tert-butoxycarbonylamino-ai-(4-hydroxyphenyl)acetic acid synthesis method, comprising the following steps: equipped with a stirrer, a reflux condenser, a thermometer, a reaction vessel was added 200ml with propionitrile solution, 0.06mol D-( I )-p-Hydroxyphenylglycine, 0.08mol sodium bromide solution, controlling the stirring speed at 160-190rpm, stirring time within 90-120min, 0.081-0.085mol tert-butoxycarbonyl bromide was slowly added in batches, controlling the solution temperature at 60--65 C, the reaction time is about 19-20h, diluted with 500ml potassium bromide solution, extracted with ethylenediamine 6-8 times, the aqueous layer was washed with oxalic acid solution, controlling pH of the solution to 5-6, potassium bromide solution was added to saturated, extracted with ethylenediamine for 4-5 times, the extract dehydrated with calcium chloride, vacuum distillation, the solvent was distilled off, the residue was added butanol solution, the solid was pulverized, filtered, got D-a-tert-butoxycarbonylamino-a-(4-hydroxyphenyl)-acetic acid.
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