Perhexiline drug intermediates a-(2,2- diphenyl-vinyl) pyridine synthesis method

摘要

#$%^&*AU2016102318A420170223.pdf#####ABSTRACT Perhexiline drug intermediates a-(2,2-diphenyl-vinyl) pyridine synthesis method, comprising the following steps: equipped with a stirrer, a reflux condenser, a thermometer, a dropping funnel, a reaction vessel was added 1.56mol 1,1-diphenyl-2 (- pyridyl) ethylamine (2), 1.8-2.1mol hypochlorous acid phenyl ester solution (3), 300ml nitromethane solution, controlling the stirring speed at 150-190rpm, the solution temperature is raised to 80-85 C, reacted for 3-5h, the temperature of the solution is reduced to 45-50'C, potassium carbonate solution was added, the pH was adjusted to 9-10, the reaction continued stirring for 5-7h, the temperature of the solution is reduced to 10-15'C, the precipitated solid was suction filtered, washed with salt solution, washed with chlorobenzene solution, zeolite decolorization, stirred and reflux for 3-4h, dehydrated with dehydrating agent, recrystallized from p-xylene solution, got crystalsa -(2,2-diphenyl-vinyl) pyridine.