POLYPEPTIDE GLYCOPEPTIDE FRAGMENTS FROM THE V1/V2 AND V3 DOMAINS OF THE HIV-1 ENVELOPE PROTEIN GP 120

摘要

Creation of HIV-1 vaccine immunogens based on glycopeptide scaffolds containing sequences from the V1/V2/V3 and C3 domains of HIV-1 gpl20 that is able to bind multiple broadly neutralizing antibodies when expressed in mammalian cells that incorporate mannose-5 and mannose-9 glycans.