Method of treating refractory rheumatoid arthritis

摘要

#$%^&*AU2017100944A420170803.pdf#####ABSTRACT Method for treating a subject suffering from refractory rheumatoid arthritis comprising the step of administering an effective amount of a quinonemethide triterpenoid or a pharmaceutically tolerable salt, solvate or anhydrate thereof to the subject. Also is a 5 method for inducing autophagy in a synovial fibroblast, and a method of inducing calcium mobilization in a synovial fibroblast. Further is a pharmaceutical composition comprising an effective dose of a quinonemethide triterpenoid and an anti-arthritis compound. It has been found that the quinonemethide triterpenoid is suitable to treat refractory rheumatoid arthritis (RA) in particular ABC-protein-dependent RA and 10 apoptosis-deficient RA. The quinonemethide triterpenoid also possesses significant inhibitory effects on the growth of synovial fibroblasts, in particular modulating the calcium homeostasis in multidrug-resistant rheumatoid arthritis synovial fibroblasts.1 /24 Ftrl 10mins 15p-30mins 15p 60mins 15p- 240rmins Fig. 1 A