Method for evaluating aspirin resistance-related genes using exome sequencing data

摘要

#$%^&*AU2017101167A420171102.pdf#####ABSTRACT The invention introduces a method for evaluating aspirin resistance-related genes using exome sequencing data. The method uses BWA, GATK, and Python to detect potential genetic mutations. Furthermore, by analyzing the generated data, a customized treatment plan for aspirin resistant patients can be obtained. The main steps include: mapping genetic sequences; locating the potential single nucleotide polymorphisms (SNPs); extracting the genetic data on individual exome. 1AnalysisRaw Reads Variance Ready Calling Variants Map to Joining Variants Reference Genotyping Evaluation By RWA Mark Duplicates Raw Variants By Picard Base Variant Recalibratio Recalibratio n n Analysis- Filtered Ready Variants Reads Figure 1 1